Primary Reduction Malformation with Bendectin.

Abstract

Summary: Animal and human studies of the teratogenic effects of anti-histaminic anti-emetics have yielded conflicting results. We report here, the case of an infant with multiple congenital anomalies of the appendicular skeleton born to a mother who was exposed to Bendectin** at the critical time of limb deve lopment in first trimester of pregnancy. While a cause-and-effect relationship cannot be positively proved, this association raises the possibility that Bendectin may be teratogenic in man. The observed low incidence of congenital malformations seen with this drug may reflect pharmacogenetic differences of the population at risk.