Effects of Routes of Administration on the Toxicityof Cow's Urine Concoction (CUC) in Mice.

Abstract

Summary:. A study of the effects of different routes of administration on the acute toxicity of cow's urine concoction (CUC) in mice was undertaken. The response to CUC was measured as the rate of convulsion and/or death of the animals. The study showed that the subcutaneous (sc) route was the least toxic, while the oral, intramuscular (im) and intraperitoneal (ip) routes had toxicity ratios of 1.51, 2.89 and 4.95 when compared with the sc route. CUC acted faster when given by the im and ip routes compared with the oral and sc routes. Since CUC is usually given orally in man, the results underscore the need for caution in extrapolating results of animal ex periments in which CUC had not been administered orally to what might happen in man.