Acute Phase Proteins in Small-for-Dates Babies.
Abstract
Summary: Alpha 1 antitrypsin, alpha 2 macroglobulin and C reactive protein (CRP) levels were measured in 18 small-for-dates (SFD) and 43 appropriate-for-dates (AFD) babies using the single radial immunodiffusion method. Mean concentration of alpha 1 antitrypsin was significantly higher (625+218mg/dl) in SFD babies than in AFD babies (450+246mg/dl) (p<0.01). However, no differences were observed in the mean levels of alpha 2 macroglobulins between the SFD (234+46mg/dl) and AFD (232+49mg/dl) babies. None of the SFD babies showed any detectable level of CRP whereas , 6 of the 43 AFD babies had detectable circulating CRP levels. Our findings on the 3 acute phase proteirs in SFD babies in this study were different from those previously reported in post-natal malnutrition.
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