Antibiotic Resistance among bacterial Isolates in Neonatal Septicaemia

Abstract

Summary: Antibiotic-resistant organisms in septicaemia is reported. This prospective study has revealed an overall rate of septicaemia as being 27.95 per 1000 live births at the Ogun State Uni versity Teaching Hospital (OSUTH). The commonest causative organ ism in the series was Klebsiella species, being responsible for 52.9 per cent of the bacterial isolates in both in-born and out-born patients. Staph aureus and E coli respectively, were the second with 29.4 percent and third with 7.4 percent causative organisms. Klebsiella species was also the commonest resistant isolate with 48 percent resistance in the series. By contrast, 91 percent of other gram-negative organisms were sensitive to gentamicin. The overall 63 percent sensitivity of all the gram-negative organisms to gentamicin in the present series, indicated a declining trend since 1977, from previous findings in different centres in the country. The use of cefotaxime or amikacin as "initial" therapy while awaiting culture results, is recommended.