Emergence of Multidrug Resistant Bacteria in Neonatal infectious: Implication for Institutional Antibiotic Formularies

Abstract

R Onalo', AT Olayinka-, WN Ogala

Abstract Background: Multidrug resistant bacteria are not uncommon in neonatal infections, hence the need on monitor the resistance pattern of offending organism and periodically modifying the emprical  treatment practical.

Objective: To determine the magnitude of multidrug resistant pathogens in new born with systematic bacterial  infections.

Patients and Methods: Records of neonates treated for septicaemia in the Special Baby Care Unit of Ahmadu Bello University Teaching Hospital, Zaria, trom April 1, 2004 to March 31, 2008 were retrieved and results of microbiological studies extracted. Data were analyzed with Epi Info version 6 software. Statistical significance was set up <0.05.

Results: Of the 575 neonates evaluated sur septicaenia, 123 had 200 bacteria isolated from blood and other sites. Predominant isolates were Staphlocucu aures (50.0 percent), Klebsiella species (18.0 percent) and Escherichia coli (14.5 percent), Multidrug-resistance was scl with Stapiņas PSS (3.0 percent), Lisokerid (3.4 percent), Proteus species (11.1 percent) and Klebsiella species (22.2 percent).

Conclusions: The resistance pattern suggests the mood to modify the empirical treatment protocol as follows: crythromycin for superficial infections, a combination of doxicillin and geramican for deep-seated infections. However, in severe deep-seated infections and interagitis, cefurtxime and ceftriaxone respectively should be used in place of cloxacillin. Further studies are needed to identify the most appropriate antibiotics for treating multidrug resistant bacteria .

Keywords: Bacterial agents, neonates, septicaemia, antibiotics resistance