Ocularhaemodynamics parameters of asymptomatic HAART experienced HIV-infected under-five children

Authors

  • Ajulo MO Department of Clinical Pharmacy and Biopharmacy
  • Omole MK Department of Clinical Pharmacy and Pharmacy Administration,
  • Moody JO Department of Pharmacognosy,
  • Olusanya BA Department of Ophthalmology,

Abstract

Abstract:

Objectives: Study aimed at evaluating the impacts of HAART on retinal blood flow of a symptomatic H A A R T - experienced HIV-infected underfive children. Method: Ethical approval and patient consents were obtained before commencement of the study in the selected hospitals. Thirty asymptomatic HAARTexperienced HIV-infected children and three seronegative children aged 0-5 year-old fulfilled conditions for ocular ultrasonography among 60 conveniencesampled under-fives. Ocular ultrasonography
was done on the patients in supine position with eyes closed as instructed by the radiologist. Maximum velocity (Vmax), pulsatility index (PI), resistive index (RI), optic nerve diameter, lens thickness and axial diameter were measured. Results of HAART-experienced children were not compared with the control children because of unequal size. Data were analysed by using ANOVA and level of significance was onsidered at p<0.05.

Results: Vmax of blood flow in central retinal artery (CRA) of a symptomatic H A A R T - experienced HIV-infected children was 12.2cm/s while that of seronegative children was 13.4 cm/s. The PI and RI of blood flow in CRA of asymptomatic HAARTexperienced HIV-infected children were 0.8 and 0.5 respectively while those of the seronegative children were 0.6 and 0.4 respectively.Reduced Vmax of blood flow of CRA was significantly associated with both increased PI and RI of asymptomatic HAARTexperienced HIV-infected underfive children.

Discussion: Vmax of CRA of asymptomatic HAART-experienced HIV-infected children was reduced because of their increased PI and RI suggesting an increased resistance to blood flow in asymptomatic HAART-experienced HIVinfected children.

Conclusion: Reduced Vmax of blood flow to CRA was significantly associated with increased PI and RI of asymptomatic HAARTexperienced HIV-infected children.

Keywords: Ophthalmic artery, Central retina artery, Maximumvelocity, Serop ositive children, HAART

Author Biographies

  • Ajulo MO, Department of Clinical Pharmacy and Biopharmacy


    University of Uyo,
    Uyo. Akwa-Ibom State.
    Nigeria.

  • Omole MK, Department of Clinical Pharmacy and Pharmacy Administration,


    Faculty of Pharmacy
    University of Ibadan,
    Ibadan. Oyo State. Nigeria.

  • Moody JO, Department of Pharmacognosy,



    University of Ibadan,
    Ibadan. Oyo State. Nigeria.

  • Olusanya BA, Department of Ophthalmology,



    College of Medicine,
    University of Ibadan,
    University College Hospital,
    Ibadan. Oyo State. Nigeria.

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Published

2024-07-02

Issue

Vol. 43 No. 1 (2016): Nigerian Journal of Paediatrics

Section

ORIGINALS

License

This is an open-access journal, and articles are distributed under the terms of the Creative Commons Attribution 4.0 License, which allows others to remix, transform, and build upon the work even, commercially, as long as appropriate credit is given to the author, and the new creations are licensed under identical terms

How to Cite

Ocularhaemodynamics parameters of asymptomatic HAART experienced HIV-infected under-five children. (2024). NIGERIAN JOURNAL OF PAEDIATRICS, 43(1), 20-25. https://www.njpaediatrics.com/index.php/njp/article/view/222