Serum brain natriuretic peptide in healthy Nigerian newborn babies

Authors

  • Amudalat Issa Department of Paediatrics
  • Mohammed B Abdulkadir Department of Paediatrics and Child Health
  • Omotayo O Adesiyun Department of Paediatrics and Child Health
  • Bilkis  Owolabi Department of Paediatrics and Child Health
  • Surajudeen O Bello Department of Paediatrics and Child Health
  • Ruqayat R Bakare Department of Paediatrics and Child Health

Abstract

Abstract:

 Background: Brain natriuretic peptide (BNP) is a sensitive biomarker that is valuable in the management of childhood heart failure. Studies have reported racial differences in the level of BNP, especially in the adult population. The level of BNP in healthy Nigerian newborn babies is unknown. Hence, we determined the level of BNP in healthy term appropriate for gestational age (AGA) newborn babies.

Methods: This was a cross - sectional study,85 healthy term AGA newborn babies aged 24 to

72 hours. The babies had relevant demographic parameters documented in a proforma and BNP assay analysed using ELISA method.

Results: The median IQR serum BNP level was 341.43 (313.39 to 425.45) pg/ml. The median level in females, was higher than males, {393.86 (296.97- 460.62) pg/ml vs328.05 (313.61-389.39) pg/ml, p >0.05}. There was no significant relationship between serum BNP and birth weight, chronological age, gestational age, or mode of delivery (p>0.05 in each case).

Conclusion: The study demonstrated high BNP levels in healthy term Nigerian newborns. There was no relationship between BNP, the chronological age, birth weight, gender, gestational age or mode of delivery in babies between 24 to 72 hours of life.

Keywords: Brain natriuretic peptide, term babies, healthy, Nigeria

Author Biographies

  • Amudalat Issa, Department of Paediatrics
    Children Specialist Hospital, Ilorin, Nigeria
  • Mohammed B Abdulkadir, Department of Paediatrics and Child Health

    University of IlorinTeaching Hospital

    University of Ilorin, Nigeria

  • Omotayo O Adesiyun, Department of Paediatrics and Child Health

     University of Ilorin Teaching Hospital

     University of Ilorin, Nigeria

  • Bilkis  Owolabi, Department of Paediatrics and Child Health
    General Hospital, Ilorin, Nigeria
  • Surajudeen O Bello, Department of Paediatrics and Child Health
    Dalhatu Araf Specialist Hospital, Lafia Nasarawa State
  • Ruqayat R Bakare, Department of Paediatrics and Child Health
      University of IlorinTeaching Hospital University of Ilorin, Nigeria

Published

2021-03-01

Issue

Vol. 48 No. 1 (2021): Nigerian Journal of Paediatrics

Section

ORIGINALS

License

This is an open-access journal, and articles are distributed under the terms of the Creative Commons Attribution 4.0 License, which allows others to remix, transform, and build upon the work even, commercially, as long as appropriate credit is given to the author, and the new creations are licensed under identical terms

How to Cite

Serum brain natriuretic peptide in healthy Nigerian newborn babies. (2021). NIGERIAN JOURNAL OF PAEDIATRICS, 48(1), 8 – 11. https://www.njpaediatrics.com/index.php/njp/article/view/18